tatpipТехника и технология пищевых производствFood Processing: Techniques and Technology2074-94142313-1748Кемеровский государственный университет10.21603/2074-9414-2025-1-2563tatpip-109Research ArticleСтатьиПотенциал транс-коричной кислоты для профилактики метаболического синдромаAnti-Metabolic Syndrome Effect of Trans-Cinnamic Acidhttps://orcid.org/0009-0002-3826-8048ЧекушкинаД. Ю.ChekushkinaD. Yu.

Кемерово

Darya Yu. Chekushkina

Kemerovo

chekushkina02@mail.ruhttps://orcid.org/0000-0002-8071-4411ФедороваА. М.FedorovaA. M.

Кемерово

Anastasia M. Fedorova

Kemerovo

https://orcid.org/0009-0006-2889-4458КоваленкоС. В.KovalenkoA. V.

Кемерово

Svetlana V. Kovalenko

Kemerovo

https://orcid.org/0000-0002-3536-562XМилентьеваИ. С.MilentyevaI. S.

Кемерово

Irina S. Milentyeva

Kemerovo

https://orcid.org/0000-0001-7035-673XАльтшулерО. Г.AltshulerO. G.

Кемерово

Olga G. Altshuler

Kemerovo

АксеноваЛ. М.AksenovaL. M.

Москва

Larisa M. Aksenova

Moscow

Кемеровский государственный университетРоссияKemerovo State UniversityRussian FederationВсероссийский научно-исследовательский институт кондитерской промышленностиРоссияAll-Russian Scientific Research Institute of Confectionery IndustryRussian Federation202519082026551136147Copyright © Чекушкина Д.Ю., Федорова А.М., Коваленко С.В., Милентьева И.С., Альтшулер О.Г., Аксенова Л.М., 20262026Чекушкина Д.Ю., Федорова А.М., Коваленко С.В., Милентьева И.С., Альтшулер О.Г., Аксенова Л.М.Chekushkina D.Y., Fedorova A.M., Kovalenko A.V., Milentyeva I.S., Altshuler O.G., Aksenova L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.fptt.ru/jour/article/view/109

Метаболический синдром, также известный как синдром Х или синдром резистентности к инсулину, является глобальной проблемой человечества, характеризующейся висцеральным ожирением, резистентностью к инсулину, высоким кровяным давлением, гипогликемией, гипохолестеринемией и сердечно-сосудистыми заболеваниями. Цель данного исследования – изучить потенциал профилактики метаболического синдрома с помощью смесей биологически активных веществ, состоящих из рутина (RUT), кверцетина (KVC) и транс-коричной кислоты (TKR-k), в составе которых преобладает TKR-k.

Объектами исследований послужили смеси биологически активных веществ, включающие транс-коричную кислоту, рутин и кверцетин в различных соотношениях: смесь № 1 – RUT:KVC:TKR-k в соотношении 1:1:2, смесь № 2 – RUT:TKR-k в соотношении 1:3, смесь № 3 – RUT:KVC:TKR-k в соотношении 4:1:15, смесь № 4 – KVC:TKR-k в соотношении 3:1. Определение гипохолестеринемической активности исследуемых растворов биологически активных веществ в эффективной дозе 100,0 мг/кг осуществлялось на модельных объектах (самцах черных мышей), у которых моделировали гиперхолестеринемию введением ингибитора липопротеинлипазы – полоксамера P407 в эффективной дозе 400,0 мг/кг. Определение гипогликемической активности проводилось in vivo. За час до запланированного времени введения смесей модельным объектам проводилась предварительная подготовка, в процессе которой каждую крысу взвешивали и подбирали индивидуально необходимую концентрацию смесей в эффективной дозе 100,0 мг/кг, глибенкламида – 5,0 мг/кг и глюкозы – 2000,0 мг/кг. Затем производили забор крови из кончика хвоста для протоколирования входных данных об уровне глюкозы и общего холестерина.

По результатам исследования выявлено достоверное снижение площади под кривой «концентрация глюкозы – время» (смесь № 3) (p < 0,01), что свидетельствует о гипогликемической активности. Зафиксирована тенденция снижения глюкозы во всех экспериментальных группах, однако достоверно уровень глюкозы в данной модели был снижен только в смеси № 3. Установлено, что смеси № 1–4 обладают выраженным достоверным гипохолестеринемическим эффектом. При определении уровня триглицеридов и липопротеинов низкой плотности статистически значимых различий между группами обнаружено не было, однако наблюдались тренды снижения триглицеридов в смесях № 2 и 3 и липопротеинов низкой плотности (смеси № 1 и 4).

Полученные результаты свидетельствуют о том, что целесообразнее использовать смеси № 2–4 как источники для создания биологически активных добавок, направленных на профилактику метаболического синдрома.

The metabolic syndrome, also known as syndrome X or insulin resistance syndrome, is a global human health issue. It is asso ciated with visceral obesity, insulin resistance, high blood pressure, hypoglycemia, hypocholesterolemia, and cardiovascular diseases. This article describes the anti-metabolic syndrome effect of several biologically active mixes that consisted of rutin, quercetin, and trans-cinnamic acid.

The experimental mixes differed in composition and ratio, with trans-cinnamic acid being the most abundant component. Mix 1 included rutin, quercetin, and trans-cinnamic acid (1:1:2), Mix 2 consisted of rutin and trans-cinnamic acid (1:3), Mix 3 was a combination of rutin, quercetin, and trans-cinnamic acid (4:1:15), Mix 4 consisted of quercetin and trans-cinnamic acid (3:1). The effective dose was 100.0 mg/kg for all samples. The hypocholesterolemic activity was studied on 48 male black C57Bl/6 mice with hypercholesterolemia induced by lipoprotein lipase inhibitor Poloxamer 407 (400.0 mg/kg). The hypoglycemic acti vity was determined in vivo on 42 white Wistar rats. Each rat was administered with an individual concentration of the experi mental mix (effective doses: 100.0 mg/kg for the mixes, 5.0 mg/kg for glibenclamide, and 2 000.0 mg/kg for glucose). Blood was sampled from the tip of the tail to record the input data on glucose and total cholesterol.

The study revealed a reliable decrease (p < 0.01) in the area under curve for glucose concentration and time (Mix 3), which indicated hypoglycemic potential. All groups demonstrated a certain decrease in glucose, but it was statistically significant only in the animals that received Mix 3. All the mixes exhibited a reliable hypocholesterolemic effect. The tests on triglycerides and low-density lipoproteins revealed no statistically significant differences between the experimental groups. However, those treated with Mixes 2 and 3 demonstrated a trend towards lower triglycerides, and those that received Mixes 1 and 4 had a lower level of low-density lipoproteins.

Mixes 2 (rutin + trans-cinnamic acid, 1:3), 3 (rutin + quercetin + trans-cinnamic acid, 4:1:15), and 4 (quercetin + trans-cinnamic acid, 3:1) proved to be suitable for anti-metabolic syndrome bioactive additives.

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The authors declare that there are no conflicts of interest present.